abstract：WHAT IS KNOWN AND OBJECTIVE:Gabapentin, a γ-aminobutyric acid derivative, is used for the treatment of partial onset seizures, postherpetic neuralgia, diabetic neuropathy and a host of other neurological disorders. CASE DESCRIPTION:A 44-year-old woman with spinal stenosis was prescribed gabapentin for pain. Two months...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tellor KB,Ngo-Lam R,Badran D,Armbruster AL,Schwarze MW

更新日期：2019-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Appraisal of drug information centres (DICs) is mainly by word of mouth communication and surveys of overall user satisfaction. Efforts to study the impact of this type of informatics and decision support systematically are generally lacking within the healthcare system. COMMENT:Scandinavia...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Schjøtt J,Spigset O

更新日期：2019-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Increasing reports of the combined use of vancomycin (VAN) and piperacillin/tazobactam leading to higher nephrotoxicity have led to carbapenems being recommended as an alternative option to combine with VAN when nephrotoxicity is a major concern. However, whether carbapenems also increase th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhang T,Cheng H,Li Y,Dong YZ,Zhang Y,Cheng XL,Wang AM,Dong YL

更新日期：2019-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Alzheimer's disease (AD) is the most common cause of dementia among the elderly. The exact cause of the disease is not clearly known, and no existing therapies are able to prevent disease progression. Identification of the possible "impaired brain insulin signalling in AD" enriched the scope...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Jojo GM,Kuppusamy G

更新日期：2019-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Pregabalin is used for neuropathic and postherpetic pain and generalized anxiety. The aim of this study was to obtain the onset profiles of adverse events (AE) related to falls (AEFs) such as "somnolence," "dizziness," "loss of consciousness" and "fall" onset and several clinical factor comb...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mukai R,Hasegawa S,Umetsu R,Nakao S,Shimada K,Uranishi H,Masuta M,Suzuki H,Nishibata Y,Nakamura M

更新日期：2019-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The most appropriate sedative agent for conscious sedation in minor hysteroscopic surgeries is still unclear. Dexmedetomidine a sedative and analgesic agent, may be appropriate for outpatient procedures. The aim of our study was to compare the sedative, analgesic and hemodynamic effects of d...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Bingol Tanriverdi T,Koceroglu I,Devrim S,Gura Celik M

更新日期：2019-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:An imbalance in the genetically controlled pro- and anti-inflammatory cytokine production could potentially promote ongoing low-grade inflammation following an episode of acute gastroenteritis and, subsequently, could result in irritable bowel syndrome (IBS; post-infectious IBS, PI-IBS). Sin...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sun MH,Sun LQ,Guo GL,Zhang S

更新日期：2019-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Based on spontaneous reports from Spain, it is claimed that the British, Irish and Scandinavians are at a greater risk of dipyrone-induced agranulocytosis. This report examines the evidence. COMMENT:Although interethnic differences in drug response are well known, there are no reliable epid...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shah RR

更新日期：2019-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Lemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole. CASE DESCRIPTION:We present two cases of Lemierr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Le C,Gennaro D,Marshall D,Alaev O,Bryan A,Gelfman A,Wang Z

更新日期：2019-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder. Selective serotonin reuptake inhibitors (SSRIs) are the first line of medication for OCD treatment; however, 40%-60% of patients with OCD do not respond to SSRIs adequately. There are growing pieces of evidence which...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Abdolhosseinzadeh S,Sina M,Ahmadiani A,Asadi S,Shams J

更新日期：2019-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Moringa oleifera (MO) Lam (Moringaceae) is commonly used as food supplement and as medicine in most African countries where malaria is also endemic. Therefore, co-administration of MO with antimalarials is a possibility. This study investigated the effects of MO leaves powder on the pharmaco...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Olawoye OS,Adeagbo BA,Bolaji OO

更新日期：2018-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Clinically validated pharmacogenomic information useful for patient selection and/or dose adjustment is included in drug labels. However, the label information may differ among countries. This commentary summarizes the pharmacogenomic information on drug labels in different countries. COMME...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Imatoh T,Sai K,Saito Y

更新日期：2018-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Different population pharmacokinetics (PPK) models of tacrolimus have been established in various populations. However, the tacrolimus PPK model in paediatric systemic lupus erythematosus (PSLE) is still undefined. This study aimed to establish the tacrolimus PPK model in Chinese PSLE. MET...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Wang DD,Lu JM,Li Q,Li ZP

更新日期：2018-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) are at higher risk of thrombotic complications. Studies have indicated that patients with T2DM have impaired clopidogrel-induced antiplatelet effect. Ticagrelor and prasugrel are two latest generation P2Y12 inhibitors with advantageous platelet i...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shang LL,Guo DD,Zhao HY,Quan AJ,Cao PG

更新日期：2018-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study developed a population pharmacokinetic (PK) model of levetiracetam (LEV) for treating neonatal seizures (NS) and determined the influence of clinically relevant covariates to explain the interindividual variability and residual error. METHODS:Twenty newborns admitted to the Neona...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lima-Rogel V,López-López EJ,Medellín-Garibay SE,Gómez-Ruiz LM,Romero-Méndez C,Milán-Segovia RC,Romano-Moreno S

更新日期：2018-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Beginning in the 1950s, a family of potent opioids was synthesized and developed (fentanyl and analogues). They continue to serve as valuable analgesic agents. But the recent spike and notoriety of their abuse has raised alarm, even calls for tighter control. We review the trajectory of thes...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Raffa RB,Pergolizzi JV Jr,LeQuang JA,Taylor R Jr,NEMA Research Group.,Colucci S,Annabi MH

更新日期：2018-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Long-acting formulations are an important therapeutic option for non-adherent patients with schizophrenia. There is a commonly held view that management of long-acting formulation-induced side effects is difficult. CASE DESCRIPTION:We present a patient with schizophrenia who developed acute...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Omi T,Mitsui Y,Matsunaga H

更新日期：2018-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Polypharmacy has a significant impact on patients' health with overall expenditure on over-the-counter (OTC) medicines representing a substantial burden in terms of cost of treatment. The aim of this study, which was conducted within the framework of a European Project funded by the European...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kamekis A,Bertsias A,Moschandreas J,Petelos E,Papadakaki M,Tsiantou V,Saridaki A,Symvoulakis EK,Souliotis K,Papadakis N,Faresjö T,Faresjö A,Martinez L,Agius D,Uncu Y,Sengezer T,Samoutis G,Vlcek J,Abasaeed A,Merkouri

更新日期：2018-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:There are various reasons why antiepileptic treatment can fail. One is drug-resistant epilepsies, but non-adherence, or poor adherence, to treatment may make some patients' treatment ineffective. The consequences of poor adherence include treatment failure or introduction of more complex tre...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Laville F,Montana M,Roux N,Rathelot P,Giorgi R,Vanelle P

更新日期：2018-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:In order to improve public health, it is necessary to facilitate patients' easy access to affordable high-quality primary health care, and one enhanced approach to do so may be to provide primary healthcare services in the community pharmacy setting. Discrete choice experiments to evaluate p...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Feehan M,Walsh M,Godin J,Sundwall D,Munger MA

更新日期：2017-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Scabies is recognized as a neglected tropical disease responsible for a substantial health and economic burden, especially in resource-poor communities around the world. COMMENT:There are relatively few current treatment options for scabies, and they possess important limitations. The treat...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Thomas J,Christenson JK,Walker E,Baby KE,Peterson GM

更新日期：2017-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:SB5 is a biosimilar to the reference adalimumab (ADL) currently in development. The primary study objective was to demonstrate pharmacokinetic (PK) equivalence of SB5 to European Union-sourced adalimumab (EU-ADL), and United States-sourced adalimumab (US-ADL) in healthy subjects. Safety, tol...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shin D,Lee Y,Kim H,Körnicke T,Fuhr R

更新日期：2017-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Therapeutic effects of anti-VEGF agents, corticosteroids and laser therapy have been previously examined for treating macular oedema secondary to branch and central retinal vein occlusion (BRVO and CRVO). However, anti-VEGF efficacy has not been previously compared to corticosteroid or laser...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Qian T,Zhao M,Xu X

更新日期：2017-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Massive acute arsenic poisoning is rare yet potentially life-threatening. 2,3-dimercaptopropane-1-sulphonate (DMPS) appears to have the appropriate chelating property. However, clinical experience on the use of DMPS in massive arsenic poisoning is limited. CASE DESCRIPTION:A 37-year-old wom...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lu PH,Tseng JC,Chen CK,Chen CH

更新日期：2017-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity and mortality, and frequent exacerbations are associated with an increased risk of death, deterioration in lung function and reduced quality of life. Current Australian guidelines developed by the Lung Foun...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Brownridge DJ,Zaidi STR

更新日期：2017-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Nephrotoxicity is a recognized side effect of cisplatin chemotherapy. However, the optimal strategy for preventing cisplatin-induced nephrotoxicity, if any, remains unclear. The primary objective for this study was to determine whether mannitol or furosemide provides better nephroprotection ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mach CM,Kha C,Nguyen D,Shumway J,Meaders KM,Ludwig M,Williams-Brown MY,Anderson ML

更新日期：2017-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Hyperthermia is an effective treatment modality that augments the anticancer effects of radiotherapy and chemotherapy. Hyperthermia-chemo-radiotherapy (HCRT) is a combination therapy that can strengthen anticancer effects through a synergistic interaction between heat, chemotherapy and radia...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hu Y,Li Z,Mi DH,Cao N,Zu SW,Wen ZZ,Yu XL,Qu Y

更新日期：2017-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Glucocorticoid-induced diabetes mellitus (GIDM) increases the risk of diabetes mellitus (DM)-related complications but is generally difficult to detect in clinical settings. The criteria for diagnosing GIDM have not been established. Recently, medical information databases (MIDs) have been u...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Imatoh T,Sai K,Hori K,Segawa K,Kawakami J,Kimura M,Saito Y

更新日期：2017-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The STOPP/START tool has been validated to assess elderly patients for potentially inappropriate prescribing. This study aimed to assess the effect of inclusion of a pharmacist on a physician-led ward round on potentially inappropriate prescribing in hospitalized elderly patients. METHODS:T...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Mulvogue K,Roberts JA,Coombes I,Cottrell N,Kanagarajah S,Smith A

更新日期：2017-04-01 00:00:00

abstract：WHAT IS KNOWN:The neonatal intensive care units (NICUs) are at the highest risk of drug dose error of all hospital wards. NICUs also have the most complicated prescription modalities. The computerization of the prescription process is currently recommended to decrease the risk of preventable adverse drug effects (pADEs...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gouyon B,Iacobelli S,Saliba E,Quantin C,Pignolet A,Jacqz-Aigrain E,Gouyon JB

更新日期：2017-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Recent reviews have shown that pharmacist-provided medication review in the elderly can improve clinical outcomes and reduce medication discrepancies compared with usual care. However, none determined whether these translate to improved humanistic and economic outcomes. This review sought to...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Loh ZW,Cheen MH,Wee HL

更新日期：2016-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:This study aimed to compare the ability of statin monotherapy (ST group), omega-3 fatty acid monotherapy (OM_A group) and combination therapy with omega-3 fatty acids and a statin (OM_S group), to reduce triglyceride (TG) levels in patients with hypertriglyceridaemia. METHODS:In this retros...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kim HS,Kim H,Jeong YJ,Yang SJ,Baik SJ,Lee H,Lee SH,Cho JH,Choi IY,Yim HW,Yoon KH

更新日期：2016-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Bisphosphonates are the first-line medications for treating osteoporosis. The aim of our prospective study was to compare the efficacy of zoledronate with that of alendronate in women with post-menopausal osteoporosis based on the evaluations of bone mineral density (BMD) and serum levels of...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tan W,Sun J,Zhou L,Li Y,Wu X

更新日期：2016-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The pharmacokinetic-pharmacodynamic parameter that best predicts the efficacy of vancomycin is the ratio of the area under the concentration versus time curve (AUC) to the minimum inhibitory concentration (MIC). A 24-h AUC (AUC24 )/MIC ratio ≥ 400 was recommended in an American consensus rev...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Fukumori S,Tsuji Y,Mizoguchi A,Kasai H,Ishibashi T,Iwamura N,To H

更新日期：2016-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Midazolam (MDZ) is commonly used for sedating critically ill patients. The daily dose required for adequate sedation increases in increments over 100 h after administration. The objectives of this study were to characterize the MDZ pharmacokinetics in critically ill patients and to describe ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Aoyama T,Hirata K,Yamamoto Y,Yokota H,Hayashi H,Aoyama Y,Matsumoto Y

更新日期：2016-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Limited data are available on co-administration of acenocoumarol with direct-acting antiviral agents for chronic hepatitis C virus infection. CASE SUMMARY:We report a case of a patient who required a significant increase in acenocoumarol weekly dose probably due to an interaction with ombit...

journal_title：Journal of clinical pharmacy and therapeutics

authors： de Lorenzo-Pinto A,Giménez-Manzorro Á,Rodríguez-González CG,Ahumada-Jiménez A,Herranz-Alonso A,Marzal-Alfaro MB,Sanjurjo-Sáez M

更新日期：2016-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The calcium channel blocker diltiazem has been used widely as a cyclosporine (CsA)/tacrolimus-sparing agent. However, considerable interpatient variability in diltiazem's CsA/tacrolimus-sparing effect has been observed in many clinical studies. This study was carried out to investigate the i...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zhou LY,Zuo XC,Chen K,Wang JL,Chen QJ,Zhou YN,Yuan H,Ma Y,Zhu LJ,Peng YX,Ming YZ

更新日期：2016-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:There are no clinical reports that have compared topiroxostat, a selective xanthine oxidase inhibitor, with allopurinol in serum urate-lowering efficacy. The aim of this study was to compare the efficacy and safety of topiroxostat and allopurinol in Japanese hyperuricemic patients with or wi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Hosoya T,Ogawa Y,Hashimoto H,Ohashi T,Sakamoto R

更新日期：2016-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Ceftriaxone is a third-generation cephalosporin with broad-spectrum antibacterial activity. Ceftriaxone-associated urolithiasis and post-renal acute renal failure (PARF) in adults is exceedingly rare and perhaps underappreciated. We report one such case to increase appreciation of this risk ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shen-Hua W,Fan-Yi M,Qing-Ling Z,Li-Na Z,Li-Jun M

更新日期：2016-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Aloe vera (Aloe vera (L.) Burm.f., Xanthorrhoeaceae family) has long been used in folk or traditional medicine for diabetes. Several studies have been conducted on the effect of Aloe vera on glycaemic control, but the results appear inconsistent. We undertook a systematic review and meta-ana...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Suksomboon N,Poolsup N,Punthanitisarn S

更新日期：2016-04-01 00:00:00